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This paper sheds light on the influence of corporate governance, institutional quality, human capital and firm size on financial institutions performance in Kenya using sampled data from 236 financial institutions during 2010-2015. Further, this research finds out whether the financial regulations could moderate the influence of corporate governance, institutional quality, human capital and firm size on financial institutions performance in Kenya. Stratified sampling was adopted to obtain samples from the heterogeneous financial services sector. Performance indicators used were Return on Investment (ROI) and Return on Equity (ROE) with predictors being human capital, institutional framework, firm size and corporate governance the relationship being moderated by financial regulations. The study established that the four predictors influenced financial institutions performance most of them being statistically significant except firm size. The financial regulation moderation effect was established to be significant in affecting the relationship between financial institutions performance and the predictors.